Currently, there are nearly 17,000 people waiting for liver transplants in the United States, but only enough livers to perform about 6,300 transplants each year. Because of this organ shortage, more than 1,500 people die each year while waiting for a liver transplant.
Objective
To
evaluate the long-term survival outcomes of a large cohort of liver
transplant recipients and to identify static and changing factors that
influenced these outcomes over time.
Summary Background Data
Liver
transplantation has been accepted as a therapeutic option for patients
with end-stage liver disease since 1983, with continual improvements in
patient survival as a result of advances in immunosuppression and
medical management, technical achievements, and improvements in
procurement and preservation. Although many reports, including registry
data, have delineated short-term factors that influence survival, few
reports have examined factors that affect long-term survival after liver
transplantation.
Methods
Four
thousand consecutive patients who underwent liver transplantation
between February 1981 and April 1998 were included in this analysis and
were followed up to March 2000. The effect of donor and recipient age at
the time of transplantation, recipient gender, diagnosis, and year of
transplantation were compared. Rates of retransplantation, causes of
retransplantation, and cause of death were also examined.
Results
The overall patient survival for the entire cohort was 59%; the actuarial 18-year survival was 48%. Patient survival was significantly better in children, in female recipients, and in patients who received transplants after 1990. The rates of retransplantation for acute or chronic rejection were significantly lower with tacrolimus-based immunosuppression. The risk of graft failure and death was relatively stable after the first year, with recurrence of disease, malignancies, and age-related complications being the major factors for loss.Staying positive but also facing the facts.
although i think the 'results' numbers is higher, some where around 73% as of last year. If i remember during my search for information when all this started.
never mind i was going to do the math as to the actual odds but my brain is not working.. its late, i cant sleep and i'm hurtin again.
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